Nature Communications (Jun 2022)

MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake

  • Ruiling Liu,
  • Cuilian Liu,
  • Xiaozhen He,
  • Peng Sun,
  • Bin Zhang,
  • Haoran Yang,
  • Weiyun Shi,
  • Qingguo Ruan

DOI
https://doi.org/10.1038/s41467-022-31317-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The microRNA miR-21 is induced in the islets of patients with glucose intolerance and diabetic mice. Here the authors report that deletion of miR-21 in pancreatic β-cells impairs glucose-stimulated insulin secretion via reduced glucose uptake, while a miR-21 agomir reduces blood glucose leves in diabetic male mice.