eLife (Jan 2015)
The contrasting phylodynamics of human influenza B viruses
- Dhanasekaran Vijaykrishna,
- Edward C Holmes,
- Udayan Joseph,
- Mathieu Fourment,
- Yvonne CF Su,
- Rebecca Halpin,
- Raphael TC Lee,
- Yi-Mo Deng,
- Vithiagaran Gunalan,
- Xudong Lin,
- Timothy B Stockwell,
- Nadia B Fedorova,
- Bin Zhou,
- Natalie Spirason,
- Denise Kühnert,
- Veronika Bošková,
- Tanja Stadler,
- Anna-Maria Costa,
- Dominic E Dwyer,
- Q Sue Huang,
- Lance C Jennings,
- William Rawlinson,
- Sheena G Sullivan,
- Aeron C Hurt,
- Sebastian Maurer-Stroh,
- David E Wentworth,
- Gavin JD Smith,
- Ian G Barr
Affiliations
- Dhanasekaran Vijaykrishna
- Duke-NUS Graduate Medical School, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
- Edward C Holmes
- Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
- Udayan Joseph
- Duke-NUS Graduate Medical School, Singapore, Singapore
- Mathieu Fourment
- Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
- Yvonne CF Su
- Duke-NUS Graduate Medical School, Singapore, Singapore
- Rebecca Halpin
- J Craig Venter Institute, Rockville, United States
- Raphael TC Lee
- Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
- Yi-Mo Deng
- World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
- Vithiagaran Gunalan
- Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
- Xudong Lin
- J Craig Venter Institute, Rockville, United States
- Timothy B Stockwell
- J Craig Venter Institute, Rockville, United States
- Nadia B Fedorova
- J Craig Venter Institute, Rockville, United States
- Bin Zhou
- J Craig Venter Institute, Rockville, United States
- Natalie Spirason
- World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
- Denise Kühnert
- Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland
- Veronika Bošková
- Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
- Tanja Stadler
- Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
- Anna-Maria Costa
- Royal Children's Hospital, Parkville, Australia
- Dominic E Dwyer
- Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital and University of Sydney, Westmead, Australia
- Q Sue Huang
- Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Upper Hutt, New Zealand
- Lance C Jennings
- Microbiology Department, Canterbury Health Laboratories, Christchurch, New Zealand
- William Rawlinson
- Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia
- Sheena G Sullivan
- World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; School of Population and Global Health, University of Melbourne, Melbourne, Australia
- Aeron C Hurt
- World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; School of Population and Global Health, University of Melbourne, Melbourne, Australia
- Sebastian Maurer-Stroh
- Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore; National Public Health Laboratory, Communicable Diseases Division, Ministry of Health, Singapore, Singapore
- David E Wentworth
- J Craig Venter Institute, Rockville, United States
- Gavin JD Smith
- Duke-NUS Graduate Medical School, Singapore, Singapore; World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Duke Global Health Institute, Duke University, Durham, United States
- Ian G Barr
- World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; School of Applied Sciences and Engineering, Monash University, Churchill, Australia
- DOI
- https://doi.org/10.7554/eLife.05055
- Journal volume & issue
-
Vol. 4
Abstract
A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
Keywords
