Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India
Sudheesh K. Shukla
Department of Biomedical Engineering, Shobhit Institute of Engineering & Technology (Deemed To-Be-University), Meerut 250110, UP, India
Meenakshi Choudhary
Department of Solar Energy and Environmental Physics, The Swiss Institute of Dryland, Environmental and Energy Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel
Jalaj Gupta
Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India
Priyanka Chaudhary
School of Physical & Decision Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, UP, India
Saurabh Srivastava
Department of Applied Sciences & Humanities, Rajkiya Engineering College Ambedkar Nagar, Dr. A.P.J. Abdul Kalam Technical University, Ambedkar Nagar 224122, UP, India
Mukesh Kumar
Department of Zoology, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, UP, India
Manoj Kumar
Indian Council of Medical Research—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal 462030, MP, India
Devojit Kumar Sarma
Indian Council of Medical Research—National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal 462030, MP, India
Bal Chandra Yadav
School of Physical & Decision Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow 226025, UP, India
Vinod Verma
Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India
Diabetes is a major health challenge, and it is linked to a number of serious health issues, including cardiovascular disease (heart attack and stroke), diabetic nephropathy (kidney damage or failure), and birth defects. The detection of glucose has a direct and significant clinical importance in the management of diabetes. Herein, we demonstrate the application of in-situ synthesized Ti2C-TiO2 MXene nanocomposite for high throughput non-enzymatic electrochemical sensing of glucose. The nanocomposite was synthesized by controlled oxidation of Ti2C-MXene nanosheets using H2O2 at room temperature. The oxidation results in the opening up of Ti2C-MXene nanosheets and the formation of TiO2 nanocrystals on their surfaces as revealed in microscopic and spectroscopic analysis. Nanocomposite exhibited considerably high electrochemical response than parent Ti2C MXene, and hence utilized as a novel electrode material for enzyme-free sensitive and specific detection of glucose. Developed nanocomposite-based non-enzymatic glucose sensor (NEGS) displays a wide linearity range (0.1 µM-200 µM, R2 = 0.992), high sensitivity of 75.32 μA mM−1 cm−2, a low limit of detection (0.12 μM) and a rapid response time (~3s). NEGS has further shown a high level of repeatability and selectivity for glucose in serum spiked samples. The unveiled excellent sensing performance of NEGS is credited to synergistically improved electrochemical response of Ti2C MXene and TiO2 nanoparticles. All of these attributes highlight the potential of MXene nanocomposite as a next-generation NEGS for on the spot mass screening of diabetic patients.
