mBio (Oct 2021)

Methylation of PhoP by CheR Regulates <i>Salmonella</i> Virulence

  • Yang Su,
  • Jianhui Li,
  • Wenting Zhang,
  • Jinjing Ni,
  • Rui Huang,
  • Zuoqiang Wang,
  • Sen Cheng,
  • Yue Wang,
  • Zhixin Tian,
  • Qiuxiang Zhou,
  • Donghai Lin,
  • Wenjuan Wu,
  • Christoph M. Tang,
  • Xiaoyun Liu,
  • Jie Lu,
  • Yu-Feng Yao

DOI
https://doi.org/10.1128/mBio.02099-21
Journal volume & issue
Vol. 12, no. 5

Abstract

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Posttranslational modifications (PTMs) play an important role in regulating enzyme activities, protein-protein interactions, or DNA-protein recognition and, consequently, modulate many biological functions. We demonstrated that PhoP, the response regulator of PhoP/PhoQ two-component system, could be methylated on several evolutionally conserved amino acid residues.