MODES OF INTERACTION BETWEEN SPERMATOZOID ABNORMALITIES AND CYTOKINES IN SEMINAL PLASMA FROM INFERTILE MALES

Abstract

Abstract. Spearman rank correlation analysis was applied to assess some interrelations between morphological abnormalities of spermatozoids in males with long-term infertility, and cytokine levels in their seminal plasma. Such statistical analysis has revealed a significant positive correlation between prevalence of morphologically abnormal spermatozoids and the levels of IL-1β, MIP-1β, G-CSF, along with negative relationship with IL-5 and IL-10 contents in seminal fluid. The data are, generally, demonstrating participation of cytokines in regulation of male fertility. (Med. Immunol., 2008, Vol. 10, N 2-3, pp 203-208).

Keywords

• immune system
• cytokines
• seminal fluid
• morphological abnormalities of spermatozoids
• il-1β
• mip-1β
• g-csf
• il-5
• il-10