Nature Communications (May 2022)
Mapping the cardiac vascular niche in heart failure
- Fabian Peisker,
- Maurice Halder,
- James Nagai,
- Susanne Ziegler,
- Nadine Kaesler,
- Konrad Hoeft,
- Ronghui Li,
- Eric M. J. Bindels,
- Christoph Kuppe,
- Julia Moellmann,
- Michael Lehrke,
- Christian Stoppe,
- Michael T. Schaub,
- Rebekka K. Schneider,
- Ivan Costa,
- Rafael Kramann
Affiliations
- Fabian Peisker
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- Maurice Halder
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- James Nagai
- Institute for Computational Genomics, RWTH Aachen University Hospital
- Susanne Ziegler
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- Nadine Kaesler
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- Konrad Hoeft
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- Ronghui Li
- Institute for Computational Genomics, RWTH Aachen University Hospital
- Eric M. J. Bindels
- Department of Hematology, Erasmus MC Cancer Institute
- Christoph Kuppe
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- Julia Moellmann
- Department of Cardiology, RWTH Aachen University Hospital
- Michael Lehrke
- Department of Cardiology, RWTH Aachen University Hospital
- Christian Stoppe
- Department of Anesthesiology, Intensive Care, Emergency, and Pain Medicine, University Hospital Wuerzburg
- Michael T. Schaub
- Department of Computer Science, RWTH Aachen University
- Rebekka K. Schneider
- Institute of Cell Biology, RWTH Aachen University Hospital
- Ivan Costa
- Institute for Computational Genomics, RWTH Aachen University Hospital
- Rafael Kramann
- Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Medical Faculty
- DOI
- https://doi.org/10.1038/s41467-022-30682-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
The cardiac vascular niche is of major importance in homeostasis and disease, but knowledge of its complexity in response to injury remains limited. Here we combine lineage tracing with single cell RNA sequencing to show alterations in fibroblasts, endothelial and mural cells in hypertrophic remodeling.
