Frontiers in Pediatrics (Dec 2022)
Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study
- Nathalia Garrido-Torres,
- Nathalia Garrido-Torres,
- Nathalia Garrido-Torres,
- Nathalia Garrido-Torres,
- Lucas Cerrillos,
- Susana García Cerro,
- Susana García Cerro,
- Alberto Pérez Gómez,
- Manuel Canal-Rivero,
- Manuel Canal-Rivero,
- Manuel Canal-Rivero,
- Manuel Canal-Rivero,
- Beatriz de Felipe,
- Beatriz de Felipe,
- Luis Alameda,
- Luis Alameda,
- Luis Alameda,
- Luis Alameda,
- Renata Marqués Rodríguez,
- Sergio Anillo,
- Julia Praena,
- Cristina Duque Sánchez,
- Cristina Roca,
- María Paniagua,
- Alvaro López Díaz,
- Alvaro López Díaz,
- Alvaro López Díaz,
- Rafael Romero-García,
- Rafael Romero-García,
- Rafael Romero-García,
- Peter Olbrich,
- Martín de Porres Puertas Albarracín,
- Pablo Reguera Pozuelo,
- Irene Luján Sosa,
- María Begoña Moreno Dueñas,
- Rocío Pineda Cachero,
- Lidia Zamudio Juan,
- Verónica García Rumi,
- Mercedes Guerrero Benitez,
- Rosario Figueroa,
- Antonio Manuel Martín Rendón,
- Antonio Partida,
- María Isabel Rodríguez Cocho,
- Carmen Gallardo Trujillo,
- Isabel Gallego Jiménez,
- Sarah García Spencer,
- Marta Gómez Verdugo,
- Cintia Bermejo Fernández,
- María Pérez Benito,
- Rafael Esteban Castillo Reina,
- Angela Cejudo López,
- Candela Sánchez Tomás,
- María Ángeles Chacón Gamero,
- Ana Rubio,
- Amanda Moreno Mellado,
- Víctor Ramos Herrero,
- Ella Starr,
- Marta González Fernández de Palacios,
- Elena García Victori,
- Antonio Pavón Delgado,
- Ismael Fernández Cuervo,
- Alejandro Arias Ruiz,
- Irene Esperanza Menéndez Gil,
- Inés Domínguez Gómez,
- Itziar Coca Mendoza,
- Rosa Ayesa-Arriola,
- Rosa Ayesa-Arriola,
- Lourdes Fañanas,
- Lourdes Fañanas,
- Juan C Leza,
- Juan C Leza,
- José M Cisneros,
- Javier Sánchez Céspedes,
- Ezequiel Ruiz-Mateos,
- Benedicto Crespo-Facorro,
- Benedicto Crespo-Facorro,
- Benedicto Crespo-Facorro,
- Benedicto Crespo-Facorro,
- Miguel Ruiz-Veguilla,
- Miguel Ruiz-Veguilla,
- Miguel Ruiz-Veguilla,
- Miguel Ruiz-Veguilla
Affiliations
- Nathalia Garrido-Torres
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Nathalia Garrido-Torres
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Nathalia Garrido-Torres
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Nathalia Garrido-Torres
- Department of Psychiatry, University of Seville, Seville, Spain
- Lucas Cerrillos
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Susana García Cerro
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Susana García Cerro
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Alberto Pérez Gómez
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- Manuel Canal-Rivero
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Manuel Canal-Rivero
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Manuel Canal-Rivero
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Manuel Canal-Rivero
- Department of Psychiatry, University of Seville, Seville, Spain
- Beatriz de Felipe
- Congenital Immunity Disorders Group de Alteraciones Congénitas de Inmunidad, Seville Biomedical Research Institute, Seville, Spain
- Beatriz de Felipe
- Pediatrics, Infectious Diseases and Immunology Department, University Hospital Virgen del Rocío, Sevilla, Spain
- Luis Alameda
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Luis Alameda
- Department of Psychiatry, University of Seville, Seville, Spain
- Luis Alameda
- Service of General Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland
- Luis Alameda
- 0Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
- Renata Marqués Rodríguez
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Sergio Anillo
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Julia Praena
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Cristina Duque Sánchez
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Cristina Roca
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- María Paniagua
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- Alvaro López Díaz
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Alvaro López Díaz
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Alvaro López Díaz
- Department of Psychiatry, University of Seville, Seville, Spain
- Rafael Romero-García
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Rafael Romero-García
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Rafael Romero-García
- 2Department of Medical Physiology and Biophysics, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- Peter Olbrich
- Congenital Immunity Disorders Group de Alteraciones Congénitas de Inmunidad, Seville Biomedical Research Institute, Seville, Spain
- Martín de Porres Puertas Albarracín
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Pablo Reguera Pozuelo
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Irene Luján Sosa
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- María Begoña Moreno Dueñas
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Rocío Pineda Cachero
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Lidia Zamudio Juan
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Verónica García Rumi
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Mercedes Guerrero Benitez
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Rosario Figueroa
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Antonio Manuel Martín Rendón
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Antonio Partida
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- María Isabel Rodríguez Cocho
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Carmen Gallardo Trujillo
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Isabel Gallego Jiménez
- Department of Genetics, Reproduction and Maternal-Fetal Medicine, University Hospital Virgen del Rocío, Seville, Spain
- Sarah García Spencer
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Marta Gómez Verdugo
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Cintia Bermejo Fernández
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- María Pérez Benito
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Rafael Esteban Castillo Reina
- 3Department of family medicine, Virgen del Rocío University Hospital, Primary Care Health Centers, Seville, Spain
- Angela Cejudo López
- 3Department of family medicine, Virgen del Rocío University Hospital, Primary Care Health Centers, Seville, Spain
- Candela Sánchez Tomás
- 3Department of family medicine, Virgen del Rocío University Hospital, Primary Care Health Centers, Seville, Spain
- María Ángeles Chacón Gamero
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Ana Rubio
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Amanda Moreno Mellado
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Víctor Ramos Herrero
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Ella Starr
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Marta González Fernández de Palacios
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Elena García Victori
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Antonio Pavón Delgado
- 1Department of Pediatrics, Virgen del Rocío University Hospital / Institute of Biomedicine of Seville (IBiS), Seville, Spain
- Ismael Fernández Cuervo
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Alejandro Arias Ruiz
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Irene Esperanza Menéndez Gil
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Inés Domínguez Gómez
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Itziar Coca Mendoza
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Rosa Ayesa-Arriola
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Rosa Ayesa-Arriola
- 4Department of Psychiatry, University Hospital Marqués de Valdecilla - Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain
- Lourdes Fañanas
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Lourdes Fañanas
- 5Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona (UB), Barcelona, Spain
- Juan C Leza
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Juan C Leza
- 6Department of Pharmacology & Toxicology, Faculty of Medicine, Universidad Complutense Madrid, CIBERSAM, Imas12, IUINQ, Madrid, Spain
- José M Cisneros
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- Javier Sánchez Céspedes
- 7Viral Diseases and Infections in Immunodeficiencies Research Group, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain
- Ezequiel Ruiz-Mateos
- Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville Biomedical Research Institute (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain
- Benedicto Crespo-Facorro
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Benedicto Crespo-Facorro
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Benedicto Crespo-Facorro
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Benedicto Crespo-Facorro
- Department of Psychiatry, University of Seville, Seville, Spain
- Miguel Ruiz-Veguilla
- Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain
- Miguel Ruiz-Veguilla
- Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain
- Miguel Ruiz-Veguilla
- Spanish Network for Research in Mental Health CIBERSAM, ISCIII, Madrid, Spain
- Miguel Ruiz-Veguilla
- Department of Psychiatry, University of Seville, Seville, Spain
- DOI
- https://doi.org/10.3389/fped.2022.899445
- Journal volume & issue
-
Vol. 10
Abstract
The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.
Keywords
- pregnancy
- neurodevelomental disorders
- COVI-19 pandemic
- SARS-CoV-2
- autism (ASD)
- maternal mental health
