Journal of Clinical Medicine (Nov 2023)

Heartburn’s Hidden Impact: A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor

  • Jacob J. Gries,
  • Bing Chen,
  • Salim S. Virani,
  • Hafeez Ul Hassan Virk,
  • Hani Jneid,
  • Chayakrit Krittanawong

DOI
https://doi.org/10.3390/jcm12237400
Journal volume & issue
Vol. 12, no. 23
p. 7400

Abstract

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Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD.

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