Frontiers in Aging Neuroscience (Nov 2016)

Increase of EEG spectral theta power indicates higher risk of the development of severe cognitive decline in Parkinson’s disease after 3 years

  • Vitalii V Cozac,
  • Menorca Chaturvedi,
  • Menorca Chaturvedi,
  • Florian Hatz,
  • Antonia Meyer,
  • Peter Fuhr,
  • Ute Gschwandtner

DOI
https://doi.org/10.3389/fnagi.2016.00284
Journal volume & issue
Vol. 8

Abstract

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Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson’s disease.Methods: We prospectively investigated 37 patients with Parkinson’s disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables (global relative median power spectra) were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration.Results: The following baseline parameters significantly predicted severe cognitive decline: global relative median power theta (4-8 Hz), cognitive task performance in executive functions and working memory.Conclusions: Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.

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