Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study

Abstract

Objective: The present study was aimed to compare the effect of calcium channel blocker (Amlodipine, Cilnidipine and Diltiazem) on lipid profiles of hypertensive rats fed with high fat diet for four weeks. Methods: Hypertensive rats were randomly allocated into four groups and except hypertensive rats remaining all groups received high fat diet for 4 weeks. At the end of protocol blood pressure was measured by tail cuff method and blood is withdrawn from the retro-orbital puncture, separated serum is used for the assessment of various biochemical parameters. Finally liver and aorta isolated for histological changes. Results: Calcium channel blocker significantly reduces the lipid levels raised in hypertensive rats fed with high fat diet and also restore the pathological changes of aorta and liver tissues. Conclusion: These results indicate that they have a lipid lowering effect due to effect on different stages of metabolism of lipids.

Keywords

• Calcium channel blockers
• Hypertensive rats
• High fat diet
• Hypolipidemic effect