Computer-aided automated flow chemical synthesis of polymers
Li Yu,
Baiyang Chen,
Ziying Li,
Yue Su,
Xuesong Jiang,
Zeguang Han,
Yongfeng Zhou,
Deyue Yan,
Xinyuan Zhu,
Ruijiao Dong
Affiliations
Li Yu
Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Corresponding authors.
Baiyang Chen
Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Ziying Li
Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Yue Su
School of Chemistry and Chemical Engineering, Frontiers Science Centre for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Xuesong Jiang
School of Chemistry and Chemical Engineering, Frontiers Science Centre for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Zeguang Han
Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Yongfeng Zhou
School of Chemistry and Chemical Engineering, Frontiers Science Centre for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Deyue Yan
School of Chemistry and Chemical Engineering, Frontiers Science Centre for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Xinyuan Zhu
School of Chemistry and Chemical Engineering, Frontiers Science Centre for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Ruijiao Dong
Shanghai Centre for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Corresponding authors.
Synthetic chemistry has played a vital role in miscellaneous fields of human civilization over the past century. The synthetic stage yet remains time-consuming and labor-intensive. To overcome these limitations, automation has been introduced to transform synthetic chemistry, leading to the development of high-throughput methods for molecular discovery. Automated flow chemical synthesis (AFCS) has recently emerged as a promising candidate, offering improved efficiency, scalability, and sustainability over the well-known automated solid-phase peptide synthesis. To further advance AFCS, elements like artificial intelligence-based computer-aided structure design and synthesis planning, autonomously assembled compatible synthesis with enhanced automated process control, and autonomous optimization can be considered. This review focuses on recent advances in computer-aided automated flow chemical synthesis (CAAFCS) of polymers in living polymerization and iterative synthesis strategy. The current challenges and outlook are finally discussed for developing more powerful CAAFCS systems and expanding their applicability across numerous fields, potentially providing brand-new perspectives and guidelines for future developments in this field.
