A Simple and Efficient Synthesis of Highly Substituted Indeno[1,2-<i>b</i>]pyrrole and Acenaphtho[1,2-<i>b</i>]pyrrole Derivatives by Tandem Three-Component Reactions
Xiaodong Tang,
Songlei Zhu,
Ying Ma,
Ren Wen,
Lanqi Cen,
Panwei Gong,
Jing Wang
Affiliations
Xiaodong Tang
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
Songlei Zhu
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
Ying Ma
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
Ren Wen
Nanjing Hicin Pharmaceutical Co., Ltd., Nanjing 210009, Jiangsu, China
Lanqi Cen
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
Panwei Gong
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
Jing Wang
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China
A green, convenient and tandem procedure for the efficient synthesis of highly substituted indeno[1,2-b]pyrrole and acenaphtho[1,2-b]pyrrole derivatives by domino three-component reaction of tryptamine/benzylamine, 1,3-dicarbonyl compounds and ninhydrin/ acenaphthenequinone is described. The significant features of this procedure were characterized by mild reaction conditions, high yields, operational simplicity and it being environmentally benign.
