Co-downregulation of GRP78 and GRP94 induces apoptosis and inhibits migration in prostate cancer cells

Lu Tong; Wang Yue; Xu Kang; Zhou Zhijun; Gong Juan; Zhang Yingang; Gong Hua; Dai Qiang; Yang Jun; Xiong Biao; Song Ze; Yang Gang

doi:10.1515/biol-2019-0043

Open Life Sciences (Jul 2019)

Co-downregulation of GRP78 and GRP94 induces apoptosis and inhibits migration in prostate cancer cells

Lu Tong,
Wang Yue,
Xu Kang,
Zhou Zhijun,
Gong Juan,
Zhang Yingang,
Gong Hua,
Dai Qiang,
Yang Jun,
Xiong Biao,
Song Ze,
Yang Gang

Affiliations

Lu Tong: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Wang Yue: Sinopharm Wuhan Plasma-derived Biotherapies Co. Ltd., No.1 attached No.1, Zhengdian Gold Industrial Park Road, Jiangxia District, Wuhan, Hubei 430070, P.R.China
Xu Kang: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Zhou Zhijun: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Gong Juan: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Zhang Yingang: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Gong Hua: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Dai Qiang: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Yang Jun: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Xiong Biao: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Song Ze: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China
Yang Gang: Department of Urology, The First People's Hospital of Tianmen City, East No.1, Renmin Avenue, Tianmen City, Hubei 431700, P.R.China

DOI: https://doi.org/10.1515/biol-2019-0043
Journal volume & issue: Vol. 14, no. 1
pp. 384 – 391

Abstract

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Both glucose-regulated protein 78 kDa (GRP78) and glucose-regulated protein 94 kDa (GRP94) are important molecular chaperones that play critical roles in maintaining tumor survival and progression. This study investigated the effects in prostate cancer cells following the downregulation of GRP78 and GRP94.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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