Cytoprotective Polyketides from Sponge-Derived Fungus <i>Lopadostoma pouzarii</i>
Phan Thi Hoai Trinh,
Anton N. Yurchenko,
Olga O. Khmel,
Trang Vo Thi Dieu,
Ngo Thi Duy Ngoc,
Elena V. Girich,
Alexander S. Menshov,
Natalya Y. Kim,
Ekaterina A. Chingizova,
Tran Thi Thanh Van,
Jong Seok Lee,
Hyi-Seung Lee,
Ekaterina A. Yurchenko
Affiliations
Phan Thi Hoai Trinh
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Anton N. Yurchenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
Olga O. Khmel
Institute of High Technologies and Advanced Materials, Far Eastern Federal University, 10 Ajax Bay, Russky Island, Vladivostok 690922, Russia
Trang Vo Thi Dieu
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Ngo Thi Duy Ngoc
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Elena V. Girich
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
Alexander S. Menshov
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
Natalya Y. Kim
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
Ekaterina A. Chingizova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
Tran Thi Thanh Van
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
Jong Seok Lee
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Korea
Hyi-Seung Lee
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Korea
Ekaterina A. Yurchenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher’s method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.
