Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role model

Abstract

Abstract Recent advances in our understanding in the immune-mediated inflammatory diseases (IMID) are explored and promoted by the targeted treatment. Among these targets, cytokines and cytokine receptors have become the good candidates for the drug development. In this review, the cytokine and cytokine receptors, which are approved in IMID, are overviewed, and modalities of the treatment, the role of cytokines and cytokine receptors in each disease, and the updated molecular information by modern technologies in rheumatoid arthritis as a role model are shown and discussed for the future perspectives.

Keywords

• Immune-mediated inflammatory diseases
• Biological agents
• JAK inhibitors
• Cytokine
• Cytokine receptor