Frontiers in Immunology (Sep 2021)
Probiotic Interventions Alleviate Food Allergy Symptoms Correlated With Cesarean Section: A Murine Model
- Bi-Ying Jin,
- Bi-Ying Jin,
- Bi-Ying Jin,
- Zhen Li,
- Zhen Li,
- Zhen Li,
- Ya-Nan Xia,
- Ya-Nan Xia,
- Ya-Nan Xia,
- Li-Xiang Li,
- Li-Xiang Li,
- Li-Xiang Li,
- Zi-Xiao Zhao,
- Zi-Xiao Zhao,
- Zi-Xiao Zhao,
- Xiao-Yu Li,
- Xiao-Yu Li,
- Xiao-Yu Li,
- Yan Li,
- Yan Li,
- Yan Li,
- Bing Li,
- Bing Li,
- Bing Li,
- Ru-Chen Zhou,
- Ru-Chen Zhou,
- Ru-Chen Zhou,
- Shi-Chen Fu,
- Shi-Chen Fu,
- Shi-Chen Fu,
- Shi-Yang Li,
- Yan-Qing Li,
- Yan-Qing Li,
- Yan-Qing Li
Affiliations
- Bi-Ying Jin
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Bi-Ying Jin
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Bi-Ying Jin
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Zhen Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Zhen Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Zhen Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Ya-Nan Xia
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Ya-Nan Xia
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Ya-Nan Xia
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Li-Xiang Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Li-Xiang Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Li-Xiang Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Zi-Xiao Zhao
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Zi-Xiao Zhao
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Zi-Xiao Zhao
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Xiao-Yu Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Xiao-Yu Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Xiao-Yu Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Yan Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Yan Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Yan Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Bing Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Bing Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Bing Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Ru-Chen Zhou
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Ru-Chen Zhou
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Ru-Chen Zhou
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Shi-Chen Fu
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Shi-Chen Fu
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Shi-Chen Fu
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- Shi-Yang Li
- Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China
- Yan-Qing Li
- Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Yan-Qing Li
- Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, China
- Yan-Qing Li
- Robot Engineering Laboratory for Precise Diagnosis and Therapy of Gastrointestinal Tumor, Qilu Hospital of Shandong University, Jinan, China
- DOI
- https://doi.org/10.3389/fimmu.2021.741371
- Journal volume & issue
-
Vol. 12
Abstract
Delivery by cesarean section (CS) is linked to an increased incidence of food allergies in children and affects early gut microbiota colonization. Furthermore, emerging evidence has connected disordered intestinal microbiota to food allergies. Here, we investigated the impact of CS on a rat model for food allergy to ovalbumin (OVA). Rats delivered by CS were found to be more responsive to OVA sensitization than vaginally born ones, displaying a greater reduction in rectal temperature upon challenge, worse diarrhea, and higher levels of OVA-specific antibodies and histamine. 16S rRNA sequencing of feces revealed reduced levels of Lactobacillus and Bifidobacterium in the CS rats. Preventative supplementation with a probiotic combination containing Lactobacillus and Bifidobacterium could protect CS rats against an allergic response to OVA, indicating that the microbiota dysbiosis contributes to CS-related response. Additionally, probiotic intervention early in life might help to rebuild aberrant Th2 responses and tight junction proteins, both of which have been linked to CS-related high allergic reactions. Taken together, this study shows that disordered intestinal microbiota plays an essential role in the pathogenesis of food allergy mediated by CS. More importantly, interventions that modulate the microbiota composition in early life are therapeutically relevant for CS-related food allergies.
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