Вестник Витебского государственного медицинского университета (Feb 2023)
The evaluation of the safety of medical hemostatic foam based on aluminum and iron chlorides
Abstract
The aim of this work was to determine the effect of the concentrations of aluminum chloride and iron (III) chloride in the medical foam of hemostatic action, prepared according to a previously developed technology, on the process of postoperative complications formation during the stopping of bleeding from parenchymal organs. On the third day after the simulation of parenchymal bleeding the following safety criteria for the use of the developed drug were studied on the liver of rats: the degree of inflammation, the number of adhesions formed, the thickness and prevalence of fibrin plaque, the presence of blood clots. In addition, the postoperative activity of the operated animals was monitored. In total, 9 compositions of medical foam were studied in the range of metal chloride concentrations from 0% to 15%. Each group included 4 outbred rats of both sexes. While studying postoperative complications after the use of a composition containing 5% aluminum chloride and 10% iron (III) chloride, it was found that this combination of substances produced a strong cauterizing effect on the liver wound. When using it, multiple adhesions, a thick spreading fibrin coating, and severe inflammation of the wound were observed. Medical foam containing aluminum chloride and iron (III) chloride at concentrations of 10% and 0% as active ingredients, on the contrary, was effective and didn’t cause any significant complications. Animals in this group had no adhesive, inflammatory processes and signs of bleeding recurrence, there was a thin layer of fibrin in the area of the liver wound. Based on the data obtained and previously conducted studies, the concentrations of the active ingredients of aluminum chloride 10% and iron (III) chloride 0% were selected for inclusion in the composition of the medicine being developed.
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