Frontiers in Immunology (Mar 2022)

Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate

  • Kun Yang,
  • Kun Yang,
  • Matthew Holt,
  • Min Fan,
  • Min Fan,
  • Victor Lam,
  • Yong Yang,
  • Tuanzhu Ha,
  • Tuanzhu Ha,
  • David L. Williams,
  • David L. Williams,
  • Chuanfu Li,
  • Chuanfu Li,
  • Xiaohui Wang,
  • Xiaohui Wang

DOI
https://doi.org/10.3389/fimmu.2022.868679
Journal volume & issue
Vol. 13

Abstract

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Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury.

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