Lactococcus lactis as a Live-Vector Vaccine Platform for Parasitic Diseases

Abstract

The development of expression systems using non-pathogenic microorganisms has enabled efficient and safe platforms for medical and food applications, including functional foods with therapeutic benefits. Among non-pathogenic bacteria, Lactococcus lactis (L. lactis) is widely used in biotechnology for various applications, such as vaccine development and protein expression. L. lactis serves as an effective in vivo expression system for developing vaccines and therapeutics in medical research, particularly for parasitic diseases. This review highlights examples of L. lactis-based vaccines for parasitic diseases, demonstrating their ability to elicit protective cellular and humoral immune responses.

Keywords

• lactococcus lactis
• expression system
• live-vector vaccine
• parasitic diseases
• adjuvant