Nature Communications (Mar 2021)

Molecular correlates of muscle spindle and Golgi tendon organ afferents

  • Katherine M. Oliver,
  • Danny M. Florez-Paz,
  • Tudor Constantin Badea,
  • George Z. Mentis,
  • Vilas Menon,
  • Joriene C. de Nooij

DOI
https://doi.org/10.1038/s41467-021-21880-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Coordinated movement critically depends on sensory feedback from muscle spindles (MSs) and Golgi tendon organs (GTOs) but the afferents supplying this proprioceptive feedback have remained genetically inseparable. Here the authors use single cell transcriptome analysis to reveal the molecular basis of MS (groups Ia and II) and GTO (group Ib) afferent identities in the mouse.