Nature Communications (Feb 2017)

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction

  • Lingyan Wang,
  • Bishi Fu,
  • Wenjun Li,
  • Girish Patil,
  • Lin Liu,
  • Martin E. Dorf,
  • Shitao Li

DOI
https://doi.org/10.1038/ncomms13876
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Protein interaction networks can identify host proteins that affect virus replication. Here, the authors compare the protein interactomes of several influenza A virus strains and identify plakophilin 2 as a restriction factor that inhibits formation of the viral polymerase complex.