Nature Communications (May 2021)
Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury
- Hengwei Jin,
- Kuo Liu,
- Juan Tang,
- Xiuzhen Huang,
- Haixiao Wang,
- Qianyu Zhang,
- Huan Zhu,
- Yan Li,
- Wenjuan Pu,
- Huan Zhao,
- Lingjuan He,
- Yi Li,
- Shaohua Zhang,
- Zhenqian Zhang,
- Yufei Zhao,
- Yanqing Qin,
- Stefan Pflanz,
- Karim E. I. Kasmi,
- Weiyi Zhang,
- Zhaoyuan Liu,
- Florent Ginhoux,
- Yong Ji,
- Ben He,
- Lixin Wang,
- Bin Zhou
Affiliations
- Hengwei Jin
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Kuo Liu
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Juan Tang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Xiuzhen Huang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Haixiao Wang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Qianyu Zhang
- School of Life Science and Technology, ShanghaiTech University
- Huan Zhu
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yan Li
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Wenjuan Pu
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Huan Zhao
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Lingjuan He
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yi Li
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Shaohua Zhang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Zhenqian Zhang
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yufei Zhao
- Department of Cardiac Surgery, Zhongshan Hospital, Fudan University
- Yanqing Qin
- Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
- Stefan Pflanz
- Boehringer Ingelheim Pharma GmbH & Co KG
- Karim E. I. Kasmi
- Boehringer Ingelheim Pharma GmbH & Co KG
- Weiyi Zhang
- Boehringer Ingelheim Pharma GmbH & Co KG
- Zhaoyuan Liu
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Florent Ginhoux
- Singapore Immunology Network, Agency for Science, Technology and Research
- Yong Ji
- The Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University
- Ben He
- Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University
- Lixin Wang
- Department of Cardiac Surgery, Zhongshan Hospital, Fudan University
- Bin Zhou
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-021-23197-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.
