Nature Communications (Jun 2022)
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
- Nuzulul Kurniansyah,
- Matthew O. Goodman,
- Tanika N. Kelly,
- Tali Elfassy,
- Kerri L. Wiggins,
- Joshua C. Bis,
- Xiuqing Guo,
- Walter Palmas,
- Kent D. Taylor,
- Henry J. Lin,
- Jeffrey Haessler,
- Yan Gao,
- Daichi Shimbo,
- Jennifer A. Smith,
- Bing Yu,
- Elena V. Feofanova,
- Roelof A. J. Smit,
- Zhe Wang,
- Shih-Jen Hwang,
- Simin Liu,
- Sylvia Wassertheil-Smoller,
- JoAnn E. Manson,
- Donald M. Lloyd-Jones,
- Stephen S. Rich,
- Ruth J. F. Loos,
- Susan Redline,
- Adolfo Correa,
- Charles Kooperberg,
- Myriam Fornage,
- Robert C. Kaplan,
- Bruce M. Psaty,
- Jerome I. Rotter,
- Donna K. Arnett,
- Alanna C. Morrison,
- Nora Franceschini,
- Daniel Levy,
- the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium,
- Tamar Sofer
Affiliations
- Nuzulul Kurniansyah
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Matthew O. Goodman
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Tanika N. Kelly
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Tali Elfassy
- Department of Medicine, University of Miami Miller School of Medicine
- Kerri L. Wiggins
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Walter Palmas
- Department of Medicine, Columbia University Medical Center
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Henry J. Lin
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Jeffrey Haessler
- Division of Public Health Sciences, Fred Hutchinson Cancer Center
- Yan Gao
- The Jackson Heart Study, University of Mississippi Medical Center
- Daichi Shimbo
- Department of Medicine, Columbia University Irving Medical Center
- Jennifer A. Smith
- Department of Epidemiology, University of Michigan School of Public Health
- Bing Yu
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston
- Elena V. Feofanova
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston
- Roelof A. J. Smit
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Zhe Wang
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Shih-Jen Hwang
- Department of Biostatistics, Boston University
- Simin Liu
- Center for Global Cardiometabolic Health and Departments of Epidemiology, Medicine, and Surgery, Brown University
- Sylvia Wassertheil-Smoller
- Department of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine
- JoAnn E. Manson
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Donald M. Lloyd-Jones
- Department of Preventive Medicine, Northwestern University
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia School of Medicine
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Susan Redline
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Adolfo Correa
- Departments of Medicine and Pediatrics, University of Mississippi Medical Center
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Center
- Myriam Fornage
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston
- Robert C. Kaplan
- Division of Public Health Sciences, Fred Hutchinson Cancer Center
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Donna K. Arnett
- College of Public Health, University of Kentucky
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston
- Nora Franceschini
- Department of Epidemiology, University of North Carolina
- Daniel Levy
- The Population Sciences Branch of the National Heart, Lung and Blood Institute
- the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium
- Tamar Sofer
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/s41467-022-31080-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with higher likelihood of hypertension development 4-6 years later.
