Citrus pectin based complexes for the tetracycline delivery

Y.V. Chekunkov; S.T. Minzanova; A.V. Khabibullina; D.M. Arkhipova; L.G. Mironova; A.D. Voloshina; A.R. Khamatgalimov; V.A. Milyukov

Food Hydrocolloids for Health (Dec 2022)

Citrus pectin based complexes for the tetracycline delivery

Y.V. Chekunkov,
S.T. Minzanova,
A.V. Khabibullina,
D.M. Arkhipova,
L.G. Mironova,
A.D. Voloshina,
A.R. Khamatgalimov,
V.A. Milyukov

Affiliations

Y.V. Chekunkov: Corresponding author at: Arbuzov Institute of Organic and Physical Chemistry, Russian Academy of Sciences, FRC Kazan Scientific Center, Arbuzov Str. 8, 420088 Kazan, Russia.; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
S.T. Minzanova: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
A.V. Khabibullina: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
D.M. Arkhipova: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
L.G. Mironova: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
A.D. Voloshina: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
A.R. Khamatgalimov: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia
V.A. Milyukov: Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan 420088, Russia

Journal volume & issue: Vol. 2
p. 100100

Abstract

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This research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug ''Tetracycline''. The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The complexes demonstrated a high degree of drug binding to the polysaccharide matrix with the maximum content of tetracycline (6.68 wt %). The study of the antimicrobial activity of obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in the antimicrobial effect compared to source tetracycline. Thus, the future research towards the new design compounds based on studied complexes could make contribution to a new generation of drugs based on pectin biopolymers.

Published in Food Hydrocolloids for Health

ISSN: 2667-0259 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Medicine: Internal medicine: Specialties of internal medicine: Nutritional diseases. Deficiency diseases
Website: https://www.journals.elsevier.com/food-hydrocolloids-for-health

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