TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Zhangli Su; Ida Monshaugen; Briana Wilson; Fengbin Wang; Arne Klungland; Rune Ougland; Anindya Dutta

doi:10.1038/s41467-022-29790-8

Nature Communications (Apr 2022)

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Zhangli Su,
Ida Monshaugen,
Briana Wilson,
Fengbin Wang,
Arne Klungland,
Rune Ougland,
Anindya Dutta

Affiliations

Zhangli Su: Department of Genetics, University of Alabama
Ida Monshaugen: Department of Microbiology, Oslo University Hospital Rikshospitalet
Briana Wilson: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia
Fengbin Wang: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia
Arne Klungland: Department of Microbiology, Oslo University Hospital Rikshospitalet
Rune Ougland: Department of Microbiology, Oslo University Hospital Rikshospitalet
Anindya Dutta: Department of Genetics, University of Alabama

DOI: https://doi.org/10.1038/s41467-022-29790-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing. Higher level of m1A in bladder cancer is accompanied by gene dysregulation in unfolded protein response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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