Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan Felix; Eaazhisai Kandiah; Steven De Munck; Yehudi Bloch; Gydo C.P. van Zundert; Kris Pauwels; Ann Dansercoer; Katka Novanska; Randy J. Read; Alexandre M.J.J. Bonvin; Bjorn Vergauwen; Kenneth Verstraete; Irina Gutsche; Savvas N. Savvides

doi:10.1038/ncomms13228

Nature Communications (Nov 2016)

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan Felix,
Eaazhisai Kandiah,
Steven De Munck,
Yehudi Bloch,
Gydo C.P. van Zundert,
Kris Pauwels,
Ann Dansercoer,
Katka Novanska,
Randy J. Read,
Alexandre M.J.J. Bonvin,
Bjorn Vergauwen,
Kenneth Verstraete,
Irina Gutsche,
Savvas N. Savvides

Affiliations

Jan Felix: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Eaazhisai Kandiah: University Grenoble Alpes, CNRS, CEA, IBS
Steven De Munck: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Yehudi Bloch: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Gydo C.P. van Zundert: Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University
Kris Pauwels: VIB Structural Biology Research Center, Vrije Universiteit Brussel, Pleinlaan 2
Ann Dansercoer: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Katka Novanska: Masaryk University & CEITEC
Randy J. Read: Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge Institute for Medical Research
Alexandre M.J.J. Bonvin: Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University
Bjorn Vergauwen: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Kenneth Verstraete: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University
Irina Gutsche: University Grenoble Alpes, CNRS, CEA, IBS
Savvas N. Savvides: Department of Biochemistry and Microbiology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Ghent University

DOI: https://doi.org/10.1038/ncomms13228
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Viruses often subvert the host immune system using molecular decoys to prevent an effective immune response. Here, the authors examine the structural details of the viral decoy receptor GIF and its antagnosim of GM-CSF and IL-2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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