Nanodelivery of Dietary Polyphenols for Therapeutic Applications
Mithun Rudrapal,
Ashwini K. Mishra,
Laxmi Rani,
Khomendra K. Sarwa,
James H. Zothantluanga,
Johra Khan,
Mehnaz Kamal,
Santwana Palai,
Atul R. Bendale,
Swati G. Talele,
Vasim T. Pathan,
Laxmikant B. Borse,
Vishnu S. Neharkar,
Pravat K. Sahoo
Affiliations
Mithun Rudrapal
Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune 411019, India
Ashwini K. Mishra
Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India
Laxmi Rani
Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Gurugram 122103, India
Khomendra K. Sarwa
Department of Pharmacy, Government Girls Polytechnic, Raipur 492001, India
James H. Zothantluanga
Department of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh 786004, India
Johra Khan
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al-Majmaah 11952, Saudi Arabia
Mehnaz Kamal
Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
Santwana Palai
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology (OUAT), Bhubaneswar 751003, India
Atul R. Bendale
Sandip Institute of Pharmaceutical Sciences, Nashik 422213, India
Swati G. Talele
Sandip Institute of Pharmaceutical Sciences, Nashik 422213, India
Vasim T. Pathan
Sandip Institute of Pharmaceutical Sciences, Nashik 422213, India
Laxmikant B. Borse
Sandip Institute of Pharmaceutical Sciences, Nashik 422213, India
Vishnu S. Neharkar
Department of Pharmacology, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune 411019, India
Pravat K. Sahoo
Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India
Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.
