Asian Journal of Transfusion Science (Jan 2022)

A case of naturally occurring anti-Dia antibody in a young man

  • Salfarina Iberahim,
  • Noor Haslina Mohd Noor,
  • Mohd Nazri Hassan,
  • Rosnah Bahar,
  • Shafini Mohdmed Yusoff,
  • Marini Ramli,
  • Wan Suriana Wan Abdul Rahman,
  • Zefarina Zulkafli,
  • Marne Abdullah,
  • Ho Sook Fong,
  • Tengku Muzaffar Tengku Mohamed Shihabudin,
  • Hisham Atan Edinur,
  • Norul Hajar Che Ghazali

DOI
https://doi.org/10.4103/ajts.ajts_136_21
Journal volume & issue
Vol. 16, no. 2
pp. 276 – 279

Abstract

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The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.

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