Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor

• Hyejin Lee,
• Hongjun Jang,
• Hwan Myung,
• Angela Rivera,
• Anna F. Averette,
• Joseph Heitman,
• Jiyong Park,
• Deukjoon Kim,
• Hyoungsu Kim,
• Jiyong Hong

Affiliations

Hyejin Lee

Department of Chemistry, Duke University, Durham, North Carolina, United States

Hongjun Jang

Department of Chemistry, Duke University, Durham, North Carolina, United States

Hwan Myung

Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

Angela Rivera

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States

Anna F. Averette

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States

Joseph Heitman

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States

Jiyong Park

Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, Republic of Korea

Deukjoon Kim

College of Pharmacy, Seoul National University, Seoul, Republic of Korea

Hyoungsu Kim

College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Republic of Korea

Jiyong Hong

Department of Chemistry, Duke University, Durham, North Carolina, United States