Nature Communications (Jul 2017)
Identification of a hybrid myocardial zone in the mammalian heart after birth
- Xueying Tian,
- Yan Li,
- Lingjuan He,
- Hui Zhang,
- Xiuzhen Huang,
- Qiaozhen Liu,
- Wenjuan Pu,
- Libo Zhang,
- Yi Li,
- Huan Zhao,
- Zhifu Wang,
- Jianhong Zhu,
- Yu Nie,
- Shengshou Hu,
- David Sedmera,
- Tao P. Zhong,
- Ying Yu,
- Li Zhang,
- Yan Yan,
- Zengyong Qiao,
- Qing-Dong Wang,
- Sean M. Wu,
- William T. Pu,
- Robert H. Anderson,
- Bin Zhou
Affiliations
- Xueying Tian
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yan Li
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Lingjuan He
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Hui Zhang
- Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Xiuzhen Huang
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Qiaozhen Liu
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Wenjuan Pu
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Libo Zhang
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Yi Li
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Huan Zhao
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Zhifu Wang
- Department of Neurosurgery, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Shanghai Medical College, Fudan University
- Jianhong Zhu
- Department of Neurosurgery, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Shanghai Medical College, Fudan University
- Yu Nie
- State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
- Shengshou Hu
- State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
- David Sedmera
- Institute of Anatomy, First Faculty of Medicine, Charles University; Institute of Physiology The Czech Academy of Sciences
- Tao P. Zhong
- State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
- Ying Yu
- Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Li Zhang
- Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University
- Yan Yan
- Cardiology Department, Zhongshan Hospital, Fudan University
- Zengyong Qiao
- Department of Cardiovascular Medicine, Southern Medical University Affiliated Fengxian Hospital
- Qing-Dong Wang
- Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Clinical Development Biotech Unit, AstraZeneca
- Sean M. Wu
- Division of Cardiovascular Medicine, Department of Medicine, Stanford Cardiovascular Institute, Stanford University School of Medicine
- William T. Pu
- Harvard Stem Cell Institute, Harvard University
- Robert H. Anderson
- Institute of Genetic Medicine, Newcastle University
- Bin Zhou
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-017-00118-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Fetal trabecular muscles in the heart undergo a poorly described morphogenetic process that results into a solidified compact myocardium after birth. Tian et al. show that cardiomyocytes in the fetal compact layer also contribute to this process, forming a hybrid myocardial zone that is composed of cells derived from both trabecular and compact layers.
