Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

Abstract

Abstract A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3′-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions. Graphical Abstract

Keywords

• Dieckmann reaction
• Cyclization
• Spirooxindole
• Indole