Nature Communications (Mar 2019)

Structural basis for transcription initiation by bacterial ECF σ factors

  • Lingting Li,
  • Chengli Fang,
  • Ningning Zhuang,
  • Tiantian Wang,
  • Yu Zhang

DOI
https://doi.org/10.1038/s41467-019-09096-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Extra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holoenzyme and the ECF σ factor-RNAP transcription initiation complex.