CENPA and BRCA1 are potential biomarkers associated with immune infiltration in heart failure and pan-cancer
Jian Wang,
Lin Cai,
Gang Huang,
Chunbin Wang,
Zhen Zhang,
Junbo Xu
Affiliations
Jian Wang
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China
Lin Cai
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China
Gang Huang
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China
Chunbin Wang
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China
Zhen Zhang
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China; Chengdu Institute of Cardiovascular Disease, 82 Qinglong Street, Chengdu, 610014, China
Junbo Xu
Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China; Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong Street, Chengdu, 610014, China; Chengdu Institute of Cardiovascular Disease, 82 Qinglong Street, Chengdu, 610014, China; Corresponding author. Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Street, Chengdu, 610014, China.
Heart failure (HF) and cancer are the two leading causes of death worldwide and affect one another in a bidirectional way. We aimed to identify hub therapeutic genes as potential biomarkers for the identification and treatment of HF and cancer. Gene expression data of heart samples from patients with ischemic HF (IHF) and healthy controls were retrieved from the GSE42955 and GSE57338 databases. Difference analysis and weighted gene co-expression network analysis (WGCNA) were used to identify key modules associated with IHF. The overlapping genes were subjected to gene and protein enrichment analyses to construct a protein-protein interaction (PPI) network, which was screened for hub genes among the overlapping genes. A total of eight hub genes were subjected to correlation, immune cell infiltration, and ROC analyses. Then we analyzed the roles of two significant genes in 33 tumor types to explore their potential as common targets in HF and cancer. A total of 85 genes were identified by WGCNA and differentially expressed gene (DEG) analyses. BRCA1, MED17, CENPA, RXRA, RXRB, SMARCA2, CDCA2, and PMS2 were identified as the hub genes with IHF. Finally, CENPA and BRCA1 were identified as potential common targets for IHF and cancer. These findings provide new perspectives for expanding our understanding of the etiology and underlying mechanisms of HF and cancer.
