Nature Communications (Oct 2020)

A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida

  • Patricia Calero,
  • Daniel C. Volke,
  • Phillip T. Lowe,
  • Charlotte H. Gotfredsen,
  • David O’Hagan,
  • Pablo I. Nikel

DOI
https://doi.org/10.1038/s41467-020-18813-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic circuit to enable in vivo biofluorination in engineered Pseudomonas putida.