Effect of xenon-oxygen inhalations on functional status of cardiovascular system in oncological patients suffering chronic pain syndrome

Abstract

Purpose of the study. Assessment of xenon-oxygen inhalations effect on functional status of cardiovascular system in oncological patients with chronic pain syndrome.Materials and methods. Randomized double-blinded placebo-controlled clinical trial with assessment of xenon-oxygen inhalations effect on electrocardiogaram, blood pressure and heart rate was performed in oncological patients with chronic pain syndrome received analgetic drug therapy. 48 of them were in the main group and received xenon-oxygen-air mixture containing 50 % xenon and 50 % oxygen twice a day during 7 visits, and other 47 were in control group and received oxygen-air mixture containing 50 % oxygen. Level of pain severity according to numerical rating scale and satisfaction of patients on the base of questionary were also assessed.Results. No significant negative effects of xenon on electrocardiogaram were revealed. In the main group alike the control group the QT intervals did not increase. There were multidirectional changes of T-wave without clinical symptoms in main and control groups. Xenon had no influence on heart rate but lead to statistically significant systolic and diastolic blood pressure decrease. Pain severity was significantly alleviated in the main group from 50 [40; 60] to 40 [25; 50]%; p < 0,05. Satisfaction of the patients in xenon group was 71 % vs 11 % in control group; p = 0,0001.Conclusion. Xenon-oxygen inhalations had no negative side effects on electrocardiogram, blood pressure and heart rate in oncological patients with chronic pain syndrome. Xenon inclusion in complex therapy increased effectiveness of pain treatment and satisfaction of the patients.

Keywords

• cardiovascular system
• oncology
• chronic pain treatment
• xenon
• electrocardiogram
• qt interval
• arterial blood pressure