QT-Interval Prolongation in the Treatment of Drug-Resistant Tuberculosis

Abstract

The review analyzes the research articles, guidelines, and clinical trial results on the effect of fluoroquinolones, bedaquiline, nitroimidazoles, and clofazimine on QTc prolongation. The importance of timely and regular monitoring of cardiotoxicity and the importance of continuing clinical trials for the discovery of anti-tuberculosis drugs with a satisfactory safety profile are presented.

Keywords

• cardiac toxicity
• prolongation of qtc interval
• tuberculosis chemotherapy
• mdr/xdr-tb