Guoji Yanke Zazhi (May 2015)

Consistency analysis of Keratograph and traditional methods to evaluate tear film function

  • Pei-Yang Shen,
  • Hai-Bo Chen,
  • Hong-Shan Liu,
  • Ming-Bing Zeng,
  • Xiong-Gao Huang,
  • Jian-Qiang Xing,
  • Xing-Wu Zhong

DOI
https://doi.org/10.3980/j.issn.1672-5123.2015.5.27
Journal volume & issue
Vol. 15, no. 5
pp. 846 – 849

Abstract

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AIM: To investigate repeatability and accuracy of a latest Keratograph for evaluating the tear film stability and to compare its measurements with that of traditional examination methods. METHODS: The results of noninvasive tear film break-up time(NI-BUT)including the first tear film break-up time(BUT-f)and the average tear film break-up time(BUT-ave)were measured by Keratograph. The repeatability of the measurements was evaluated by coefficient of variation(CV)and intraclass correlation coefficient(ICC). Wilcoxon Signed-Rank test was used to compare NI-BUT with fluorescein tear film break-up time(FBUT)to confirm the correlation between NI-BUT and FBUT, Schirmer I test values. Bland-Altman analysis was used to evaluate consistency. RESULTS: The study recruited 48 subjects(48 eyes)(mean age 38.7±15.2 years). The CV and ICC of BUT-f were respectively 12.6% and 0.95, those of BUT-ave were 9.8% and 0.96. The value of BUT-f was lower than that of FBUT. The difference had statistical significance(6.16±2.46s vs 7.46±1.92s, PPCONCLUSION: Keratograph can provide NI-BUT data that has a better repeatability and reliability, which has great application prospects in diagnosis and treatment of dry eye and refractive corneal surgery.

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