Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Hossein Yazdani; Esha Kaul; Ayoob Bazgir; Dusica Maysinger; Ashok Kakkar

doi:10.3390/molecules25040857

Molecules (Feb 2020)

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Hossein Yazdani,
Esha Kaul,
Ayoob Bazgir,
Dusica Maysinger,
Ashok Kakkar

Affiliations

Hossein Yazdani: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, QC H3A 0B8, Canada
Esha Kaul: Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montréal, QC H3G 1Y6, Canada
Ayoob Bazgir: Department of Chemistry, Shahid Beheshti University G.C., Tehran 1983963113, Iran
Dusica Maysinger: Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montréal, QC H3G 1Y6, Canada
Ashok Kakkar: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, QC H3A 0B8, Canada

DOI: https://doi.org/10.3390/molecules25040857
Journal volume & issue: Vol. 25, no. 4
p. 857

Abstract

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An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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