Nature Communications (Sep 2019)

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

  • Joey Schyns,
  • Qiang Bai,
  • Cecilia Ruscitti,
  • Coraline Radermecker,
  • Sebastiaan De Schepper,
  • Svetoslav Chakarov,
  • Frédéric Farnir,
  • Dimitri Pirottin,
  • Florent Ginhoux,
  • Guy Boeckxstaens,
  • Fabrice Bureau,
  • Thomas Marichal

DOI
https://doi.org/10.1038/s41467-019-11843-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Functional diversity of tissue-resident macrophages and signals governing their ontogeny and turnover remain unknown for the majority of tissues. Here the authors describe two phenotypically and functionally distinct long-lived populations of lung interstitial macrophages and their putative blood-derived monocytic precursor.