The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders

Mariana Astiz; Isabel Heyde; Mats Ingmar Fortmann; Verena Bossung; Claudia Roll; Anja Stein; Berthold Grüttner; Wolfgang Göpel; Christoph Härtel; Jonas Obleser; Henrik Oster

doi:10.1038/s41467-020-17429-5

Nature Communications (Jul 2020)

The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders

Mariana Astiz,
Isabel Heyde,
Mats Ingmar Fortmann,
Verena Bossung,
Claudia Roll,
Anja Stein,
Berthold Grüttner,
Wolfgang Göpel,
Christoph Härtel,
Jonas Obleser,
Henrik Oster

Affiliations

Mariana Astiz: Institute of Neurobiology, Center of Brain, Behavior and Metabolism, University of Lübeck. Marie-Curie-Straße
Isabel Heyde: Institute of Neurobiology, Center of Brain, Behavior and Metabolism, University of Lübeck. Marie-Curie-Straße
Mats Ingmar Fortmann: Department of Pediatrics, University of Lübeck
Verena Bossung: Department of Women’s Health and Obstetrics University of Lübeck
Claudia Roll: Vestische Children’s Hospital Datteln, University Witten/Herdecke
Anja Stein: Department of Pediatrics I, University Hospital Essen
Berthold Grüttner: Department of Obstetrics and Gynecology, Faculty of Medicine and University Hospital Cologne, University of Cologne
Wolfgang Göpel: Department of Pediatrics, University of Lübeck
Christoph Härtel: Department of Pediatrics, University of Lübeck
Jonas Obleser: Department of Psychology, University of Lübeck
Henrik Oster: Institute of Neurobiology, Center of Brain, Behavior and Metabolism, University of Lübeck. Marie-Curie-Straße

DOI: https://doi.org/10.1038/s41467-020-17429-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Antenatal glucocorticoid therapy is indicated for mothers at risk of preterm delivery. Here, the authors show that the circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders later in life in mice and in a retrospective observational study in human infants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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