Nature Communications (Jul 2022)
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
- Tal Sharf,
- Tjitse van der Molen,
- Stella M. K. Glasauer,
- Elmer Guzman,
- Alessio P. Buccino,
- Gabriel Luna,
- Zhuowei Cheng,
- Morgane Audouard,
- Kamalini G. Ranasinghe,
- Kiwamu Kudo,
- Srikantan S. Nagarajan,
- Kenneth R. Tovar,
- Linda R. Petzold,
- Andreas Hierlemann,
- Paul K. Hansma,
- Kenneth S. Kosik
Affiliations
- Tal Sharf
- Neuroscience Research Institute, University of California Santa Barbara
- Tjitse van der Molen
- Neuroscience Research Institute, University of California Santa Barbara
- Stella M. K. Glasauer
- Neuroscience Research Institute, University of California Santa Barbara
- Elmer Guzman
- Neuroscience Research Institute, University of California Santa Barbara
- Alessio P. Buccino
- Department of Biosystems Science and Engineering, ETH Zürich
- Gabriel Luna
- Neuroscience Research Institute, University of California Santa Barbara
- Zhuowei Cheng
- Department of Computer Science, University of California Santa Barbara
- Morgane Audouard
- Neuroscience Research Institute, University of California Santa Barbara
- Kamalini G. Ranasinghe
- Memory and Aging Center, Department of Neurology, University of California San Francisco
- Kiwamu Kudo
- Department of Radiology and Biomedical Imaging, University of California San Francisco
- Srikantan S. Nagarajan
- Department of Radiology and Biomedical Imaging, University of California San Francisco
- Kenneth R. Tovar
- Neuroscience Research Institute, University of California Santa Barbara
- Linda R. Petzold
- Department of Computer Science, University of California Santa Barbara
- Andreas Hierlemann
- Department of Biosystems Science and Engineering, ETH Zürich
- Paul K. Hansma
- Neuroscience Research Institute, University of California Santa Barbara
- Kenneth S. Kosik
- Neuroscience Research Institute, University of California Santa Barbara
- DOI
- https://doi.org/10.1038/s41467-022-32115-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.
