Prospects for the Search for New Antidiabetic Agents Among Vanadium-containing Complex Compounds (Review)

Abstract

Introduction. The epidemic increase in the incidence of diabetes mellitus (DM) makes it urgent to search for new antidiabetic agents. In clinical practice, there is an urgent question about improving and/or replacing insulin therapy for the disease. Vanadium compounds are of particular interest in connection with the identification of their multifactorial effects on the body, including insulin-like and hypoglycemic properties, which opens up prospects for the creation of a new generation of therapeutic agents for the treatment of types 1 and 2 diabetes. The focus of this review is on the structure and antidiabetic properties of vanadium complexes.Text. This review is devoted to the analysis of scientific literature on studies of vanadium-containing compounds as potential antidiabetic agents. The mechanisms of antidiabetic activity of vanadium-containing complex compounds are discussed. The prospects for searching for oxovanadium(IV) complexes with O4-coordination have been assessed.Conclusion. As a result of the analysis of the literature data, it was found that vanadium-containing complex compounds have a significant potential for use as antidiabetic agents. The relevance of the search for highly effective oxo-vanadium metal complexes based on ligands close to endogenous substrates, for example, based on derivatives of aroylpyruvic acid, is shown.

Keywords

• antidiabetics
• insulinomimetics
• vanadium complexes