Synthesis and characterization of Ni2+ and Al3+ doped zinc ferrite nanoparticles for antibacterial, antioxidant, and anticancer (MCF-7) analysis

Abstract

In the present study ZnFe2O4 (ZFO), AlxZn1-xFe2O4 (ZAFO), and NixZn1-xFe2O4 (ZNFO) at (x = 0.05,0.08) NPs were synthesized to develop nanomedicines with potent anticancer, antibacterial and antioxidant properties. The results showed that synthesized NPs have better antibacterial activity against Pseudomonas aeruginosa and E. coli. In the cell line of L929 fibroblasts analysis, the LC50 value of ZAFO (0.05) and ZNFO (0.05) NPs in normal cells was almost greater than 3 times and 4 times higher than that in MCF-7 cell lines respectively. Exposure to ZAFO NPs for 24 h decreased cell viability in a dose-dependent manner with an LC50 value found to be 18.32 µg/ml. The results found that ZAFO (0.05) treatment induces significant production of ROS and the fluorescence intensity values of control and ZAFO (0.05) were 470.78 and 9938.58 respectively. In DPPH radical scavenging assay for ZFO, the IC50 value was 23.87 µg/ml, which is less than standard Ascorbic Acid (38.4205 µg/ml).

Keywords

• MCF-7
• Antibacterial
• Apoptosis
• Antioxidant
• p53 and ROS