Nature Communications (Mar 2023)
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass
- Shaan Khurshid,
- Julieta Lazarte,
- James P. Pirruccello,
- Lu-Chen Weng,
- Seung Hoan Choi,
- Amelia W. Hall,
- Xin Wang,
- Samuel F. Friedman,
- Victor Nauffal,
- Kiran J. Biddinger,
- Krishna G. Aragam,
- Puneet Batra,
- Jennifer E. Ho,
- Anthony A. Philippakis,
- Patrick T. Ellinor,
- Steven A. Lubitz
Affiliations
- Shaan Khurshid
- Cardiovascular Research Center, Massachusetts General Hospital
- Julieta Lazarte
- Cardiovascular Research Center, Massachusetts General Hospital
- James P. Pirruccello
- Cardiovascular Research Center, Massachusetts General Hospital
- Lu-Chen Weng
- Cardiovascular Research Center, Massachusetts General Hospital
- Seung Hoan Choi
- Cardiovascular Research Center, Massachusetts General Hospital
- Amelia W. Hall
- Gene Regulation Observatory, Broad Institute of Harvard and the Massachusetts Institute of Technology
- Xin Wang
- Cardiovascular Research Center, Massachusetts General Hospital
- Samuel F. Friedman
- Data Sciences Platform, Broad Institute of Harvard and the Massachusetts Institute of Technology
- Victor Nauffal
- Division of Cardiology, Brigham and Women’s Hospital
- Kiran J. Biddinger
- Cardiovascular Research Center, Massachusetts General Hospital
- Krishna G. Aragam
- Cardiovascular Research Center, Massachusetts General Hospital
- Puneet Batra
- Data Sciences Platform, Broad Institute of Harvard and the Massachusetts Institute of Technology
- Jennifer E. Ho
- Cardiovascular Disease Initiative, Broad Institute of Harvard and the Massachusetts Institute of Technology
- Anthony A. Philippakis
- Data Sciences Platform, Broad Institute of Harvard and the Massachusetts Institute of Technology
- Patrick T. Ellinor
- Cardiovascular Research Center, Massachusetts General Hospital
- Steven A. Lubitz
- Cardiovascular Research Center, Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s41467-023-37173-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
A genome-wide association study of cardiac magnetic resonance-derived left ventricular mass index including 43,000 UK Biobank participants reveals 12 associations (11 novel), implicating genes involved in cardiac contractility and cardiomyopathy.
