Frontiers in Microbiology (Sep 2021)

New Tetramic Acid Derivatives From the Deep-Sea-Derived Fungus Penicillium sp. SCSIO06868 With SARS-CoV-2 Mpro Inhibitory Activity Evaluation

  • Xiaoyan Pang,
  • Xiaoyan Pang,
  • Xiaoyan Pang,
  • Weihao Chen,
  • Xin Wang,
  • Xuefeng Zhou,
  • Xuefeng Zhou,
  • Bin Yang,
  • Bin Yang,
  • Xinpeng Tian,
  • Xinpeng Tian,
  • Junfeng Wang,
  • Junfeng Wang,
  • Shihai Xu,
  • Yonghong Liu,
  • Yonghong Liu

DOI
https://doi.org/10.3389/fmicb.2021.730807
Journal volume & issue
Vol. 12

Abstract

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Three new tetramic acid derivatives (1–3) and a new polyketide (4) along with eight known compounds (5–12) were isolated from cultures of the deep-sea-derived fungus Penicillium sp. SCSIO06868. Four new structures were elucidated by analysis of one-dimensional/two-dimensional nuclear magnetic resonance (NMR) data and high-resolution electrospray ionization mass spectrometry. Their absolute configurations were established by X-ray crystallography analysis and comparison of the experimental and reported electronic circular dichroism (ECD) values or specific optical rotation. Compound 3 exhibited potent, selective inhibitory activities against Staphylococcus aureus and methicillin-resistant S. aureus with minimum inhibitory concentration values of both 2.5 μg/ml. Also, compound 3 showed weak antiviral activity against severe acute respiratory syndrome coronavirus 2 main protease, which was responsible for the coronavirus disease 2019 pandemic.

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