Recent advances in CD8+ T cell-based immune therapies for HIV cure
Valentina Restrepo Arenas,
María T. Rugeles,
Federico Perdomo-Celis,
Natalia Taborda
Affiliations
Valentina Restrepo Arenas
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
María T. Rugeles
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
Federico Perdomo-Celis
Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, Colombia; Corresponding author. Instituto de Genética Humana, Pontificia Universidad Javeriana, Carrera 7 40-62, Bogotá 110231, Colombia.
Natalia Taborda
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia; Grupo de Investigaciones Biomédicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellin, Colombia; Corresponding author. Grupo de Investigaciones Biomédicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Calle 51 51-27, Medellin 050030, Colombia.
Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8+ T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achieve remission or cure of this infection. In this work, we review the major challenges for achieving an HIV cure, the models of HIV remission, and the mechanisms of HIV control mediated by CD8+ T cells. In addition, we discuss strategies based on this cell population that could be used in the search for an HIV cure. Finally, we analyze the current challenges and perspectives to translate this basic knowledge toward scalable HIV cure strategies.
