Features Associated with Visible Lamina Cribrosa Pores in Individuals of African Ancestry with Glaucoma: Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) Study
Jalin A. Jordan,
Ebenezer Daniel,
Yineng Chen,
Rebecca J. Salowe,
Yan Zhu,
Eydie Miller-Ellis,
Victoria Addis,
Prithvi S. Sankar,
Di Zhu,
Eli J. Smith,
Roy Lee,
Gui-Shuang Ying,
Joan M. O’Brien
Affiliations
Jalin A. Jordan
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ebenezer Daniel
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Yineng Chen
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Rebecca J. Salowe
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Yan Zhu
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Eydie Miller-Ellis
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Victoria Addis
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Prithvi S. Sankar
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Di Zhu
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Eli J. Smith
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Roy Lee
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Gui-Shuang Ying
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
Joan M. O’Brien
Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
There are scarce data regarding the rate of the occurrence of primary open-angle glaucoma (POAG) and visible lamina cribrosa pores (LCPs) in the eyes of individuals with African ancestry; the potential impact of these features on disease burden remains unknown. We recruited subjects with POAG to the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Through regression models, we evaluated the association between the presence of LCPs and various phenotypic features. In a multivariable analysis of 1187 glaucomatous eyes, LCPs were found to be more likely to be present in eyes with cup-to-disc ratios (CDR) of ≥0.9 (adjusted risk ratio (aRR) 1.11, 95%CI: 1.04–1.19, p = 0.005), eyes with cylindrical-shaped (aRR 1.22, 95%CI: 1.11–1.33) and bean pot (aRR 1.24, 95%CI: 1.13–1.36) cups versus conical cups (p p = 0.01), and the nasalization of central retinal vessels (aRR 1.33, 95%CI: 1.23–1.44), p p = 0.005 for per 0.1 increase in q0). Our large cohort of POAG cases of people with African ancestry showed that LCPs may be an important risk factor in identifying severe disease, potentially warranting closer monitoring by physicians.
