Romanian Journal of Laboratory Medicine (Jul 2022)

Downregulation of hsa-miR-4328 and target gene prediction in Acute Promyelocytic Leukemia

  • Lupu Onda T.,
  • Popescu Bogdan,
  • Avram Elena,
  • Dragomir Mihaela,
  • Cimponeriu Gheorghe Dănuț,
  • Mighiu Ioana,
  • Aposteanu Silvia,
  • Coriu Daniel

DOI
https://doi.org/10.2478/rrlm-2022-0022
Journal volume & issue
Vol. 30, no. 3
pp. 261 – 272

Abstract

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Introduction: Acute promyelocytic leukemia (APL) is defined by the PML-RARA fusion gene. APL treatment can have significant side effects, therefore the development of optimal therapeutic options is crucial. Although the study of miRNAs is still in its infancy, it has been shown that these molecules are involved in the pathogenesis of neoplasms by modulating the expression of target genes. miRNAs can be considered possible biomarkers in APL and can be used as therapeutic targets or as markers for the therapeutic response.

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