Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps

Abstract

Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment.

Keywords

• chronic rhinosinusitis
• nasal polyps
• th1 cells
• th2 cells
• th17 cells
• transcription factors