Nature Communications (Mar 2016)

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

  • David W. Salzman,
  • Kotoka Nakamura,
  • Sunitha Nallur,
  • Michelle T. Dookwah,
  • Chanatip Metheetrairut,
  • Frank J. Slack,
  • Joanne B. Weidhaas

DOI
https://doi.org/10.1038/ncomms10954
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation.